Wakix has had the biggest impact on my narcolepsy! Modafinil, Adderall, and Ritalin have also been beneficial, but not nearly as much as Wakix.

Have you tried Xyrem or Xywav? Or for daytime, Wakix? Wakix is the first non stimulant narcolepsy med on the market that works directly with your sleep/wake hormone, hypocretin. Changed my life!

The medicine that has worked best for me has been 10 mg of dextroamphetmine twice a day with an optional 3rd if needed. Extra 15 tablets per month. Insurance companies always deny because of the extra pills. Seen same doctor for 16 years. Have tried everything else out there except the newest meds. I just use GoodRx and pay out of pocket.

Wakix isn't available in my country yet, Circadian (a type of long release melatonin) helps me sleep (have done the trazodone route and it also worked), I take Cymbalta for cataplexy and I take Vyvanse for staying awake but I still have to have an hours nap at midday. And the afternoons are a bit foggy!

Sorry for my late response. I have tried Xyrem. The higher I went in doses made me sick to my stomach. I also stopped taking it because at the time my father was having heart issues. One night just after my 2nd dose of Xyrem I got a call, my dad was taken to the ER, his heart was in Afib. That was brutal staying awake and having to drive. My sleep doctor wants me to try Wakix. How does it make you feel?